The German centre-back is surplus to requirements at the Emirates after a series of error-strewn seasons at the club following his £35million move from Valencia in 2016, having struggled to live up to that price tag.
Mustafi has not made the matchday squad this season, with David Luizs arrival pushing him further down the pecking order, and he was again not involved in Sundays north London derby.
He had been linked with a switch to Roma, though they signed Chris Smalling from Manchester United instead, but Sky Germany report that a move to Serie A could be back on.
The transfer window in Italy – as with most leagues around Europe – closes on Monday evening and Juventus want to bring in a new centre-back before the deadline, with Mustafi one of their top options.
Juve skipper Chiellini requires surgery on an ACL injury on his right knee and is not expected to play again this year, with the Italian champions keen to bring in cover.
They have contacted Mustafi about a potential move to Turin, while Medhi Benatia, Dejan Lovren and Jerome Boateng are also on their radar.
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