Barca crashed out of Europe as Roma registered a 3-0 victory at the Stadio Olimpico and progressed to the semi-finals on away goals.
The La Liga leaders had control of the tie after sealing a 4-1 win at Camp Nou, but were made to pay for a woeful display in the Italian capital.
Iniesta, meanwhile, will confirm if he will stay at Camp Nou by the end of April but admits the prospect of leaving is a possibility.
When asked after the defeat to Roma if it was his last Champions League game for Barcelona, a clearly emotional Iniesta told TV3: Its one of the possibilities and thats why it hurts more.
Edin Dzeko sparked Romas revival by opening the scoring in the sixth minute before goals from Daniele De Rossi and Kostas Manolas in the second half sealed the win.
It is a very painful elimination because nobody expected it because of the lead we had, said Iniesta.
When you do things wrong, you make many mistakes and we did not adapt to the game.
It was a very big disappointment for the season we have had so far.
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