Egyptians say that all 97 million of their compatriots will be rooting for Salah when the Pharaohs kick off the tournament against Zimbabwe on Friday.
Salah, 27, will also be hoping to banish the nightmare of last year's World Cup in Russia when he played with a barely healed shoulder injury, Egypt were eliminated in the first round and their hosts in Chechnya used the team for political purposes.
He comes into the tournament on a high, having scored the second-minute penalty that put Liverpool on their way to winning the Champions League final against Tottenham in Madrid.
The Egyptian also won the Golden Boot for the top scorer in England for the second season in a row, although this time his 22 goals were equalled by Liverpool teammate Sadio Mane and Arsenal's Pierre-Emerick Aubameyang who share the award with him, making it an all-African affair.
Liverpool though were pipped to the Premier League title by Manchester City.
"As soon as Salah touches the ball, he's dangerous," Tunisia player Naim Sliti told AFP after facing Egypt in a qualifier.
"You just mustn't let him get the ball, because something always happens when he has it."
Salah's mood and fitness contrast to this time last year when his shoulder was injured as he was wrestled to the ground by Real Madrid's Sergio Ramos in the 2018 Champions League final in Kiev. He had to go off and Liverpool lost 3-1.
Although clearly not recovered, Salah arrived in Chechnya for the World Cup and was promptly paraded with the republic's president Ramzan Kadyrov.
He was only fit enough to be a substitute in the first two games but returned for the final match against Saudi Arabia and scored, but could not prevent Egypt slumping to a third defeat.
The World Cup debacle also revealed that Salah's supporting cast is nowhere near the level of their star man — everything revolves around him.
"The Egypt coaches plan their tactics around Salah," said Karim Said, chief editor of sports website Yalla Kora.
Leading his country to its eighth African title would be the crowning glory for the man who grew up in the Nile Delta village of Nagrig.
After Liverpool beat Spurs in this year's Champions League showdown, an emotional Salah said: "I made many sacrifices for my career. I came from a small village and went to Cairo. To be an Egyptian at this level (of the football world) is unbelievable."
Salah began attending Nagrig's modest sports club when he was eight years old.
"I coached Mohamed Salah when he was still a child and his talent was clear from the day he was born," Ghamri Abdelhamid Al-Saadani, his coach then, recalled to AFP.
He said Salah's success was not built on talent alone: "He had an iron will and huge amounts of perseverance."
Encouraged by his football-mad father, Salah moved on to Tanta, the main town in his home region of Gharbeya, before moving to Cairo. Opportunities in Europe soon beckoned, starting with Swiss club Basel.
In 2014, Salah moved to Chelsea but success did not come in that first stint in England. It was only when he moved to Roma that the goals began to flow and he earned his move to Liverpool.
