Stoke lost 2-1 to Crystal Palace after an injury time winner from former Liverpool defender, Mamadou Sakho.
The Reds were held to a 1-1 draw with Chelsea after Willian’s cross lobbed Simon Mignolet in the 85th minute.
Jurgen Klopp’s side will want to get back to winning ways as they face a Stoke side who have not won in three league games.
Ramadan Sobhi has been passed fit and could feature in the match.
Geoff Cameron remains sidelined due to concussion which he suffered in training at the end of October.
Jack Butland (broken finger) and Stephen Ireland (broken leg) are also unavailable for the match.
Dejan Lovren (back) and Emre Can (muscular injury) are expected to be available after they missed Saturday’s 1-1 draw with Chelsea.
Jurgen Klopp has hinted that his squad may be rotated.
Sadio Mane and Roberto Firmino were both on the subs bench for Liverpool as Jurgen Klopp made five changes from the side that drew 3-3 away to Sevilla.
They are expected to start for the Reds.
What time is Stoke vs Liverpool kick-off?
The match is on Wednesday 28 November with kick-off at 8pm.
Is Stoke vs Liverpool on TV?
The game will not be televised live in the UK.
Highlights are on Match of the Day on Wednesday 28 November at 10.45pm.
The only fixtures that will be televised live during this round of mid-week Premier League games are: Watford vs Manchester Utd on BT Sport (last night) and Everton vs West Ham on BT Sport (tonight at 8pm).
- Stoke have lost seven of their last eight games against Liverpool in the Premier League.
- Liverpool have won four of their last five away games in all competitions against Stoke, including each of the last three.
- Liverpool’s 23-point tally this season is seven points lower than they had after 13 games in 2016-17 (30).
- Daniel Sturridge has scored four and assisted one more in his five Premier League appearances against Stoke for Liverpool.
- Xherdan Shaqiri has had a hand in six goals in his last six Premier League games for Stoke City (two goals, four assists).