Arsene Wenger has opted to start with Alexandre Lacazette, Alexis Sanchez and Mesut Ozil for the first time in the Premier League.
Lacazette, the Gunners’ record signing, is yet to play alongside both of Arsenal’s star men since moving to the club from Lyon.
The Gunners beat Red Star Belgrade on Thursday thanks to a late, acrobatic effort from Olivier Giroud in Serbia and the Frenchman’s made a number of changes.
Only Petr Cech keeps his place from midweek, while Granit Xhaka also starts after his display in the defeat against Watford.
The Gunners appear to be playing in a back three and there’s a spot for Matthew Macey on the bench in David Ospina’s absence.