The Toffees have won just two of their eight Premier League matches this season, and manager Ronald Koeman remains under severe pressure following Thursday's failure to defeat Lyons in the Europa League.
Arsenal are faring slightly better, but the defeat at the hands of Watford last weekend has made it three losses in eight matches and the Gunners are already 12 points behind leaders Manchester City.
Questions about Arsene Wenger's position remain, though he is not at the same risk of losing his job as Koeman.
So, who has been selected for the clash at Goodison Park? The confirmed teams can be seen, in full, below…
Everton XI: Pickford, Keane, Jagielka, Williams, Gueye, Kenny, Sigurdsson, Vlasic, Baines, Rooney, Calvert-Lewin
Substitutes: Mirallas, Martina, Klaassen, Davies, Lookman, Robles, Niasse
Arsenal XI: Cech, Koscielny, Mertesacker, Monreal, Bellerin, Ramsey, Xhaka, Kolasinac, Ozil, Sanchez, Lacazette
Subsitutes: Wilshere, Giroud, Walcott, Holding, Iwobi, Coquelin, Macey.